MedComm-Future Medicine | Chemoimmunotherapy for esophageal squamous cell carcinoma—Summary and discussion of recent clinical trials

Comparison between traditional chemotherapy and chemoimmunotherapy. Traditional standard chemotherapy contained alkylating agents, platinum, antimetabolites, microtubule inhibitors, and so on. Each of....

2023-08-31

MedComm-Biomaterials and Applications | Recent progress in thermosensitive hydrogels and their applications in drug delivery area

Classification of the thermosensitive hydrogel.The scientific community has widely recognized thermosensitive hydrogels as highly biocompatible material with immense potential in drug delivery systems....

2023-08-31

MedComm-Oncology | cGAS-STING signaling in cancer: Regulation and therapeutic targeting

The activation and translocation of STING. STING interacts with STIM1 and localizes on the ER. When STING is not yet activated, it is in a dimeric state with an open conformation. When STING is activa....

2023-08-31

MedComm-Future Medicine | Accelerating the integration of ChatGPT and other large-scale AI models into biomedical research and healthcare

Large-scale AI models. (A) Comparison of large-scale AIs with deep learning and machine learning. (B) Overview of the most recent advanced large-scale AI models and their sizes. A summary of the lates....

2023-07-31

MedComm-Future Medicine | Biomarkers of ageing: Current state-of-art, challenges, and opportunities

Ageing biomarkers are categorized based on the data sources utilized, encompassing molecular and cellular profiles, images, clinical measures, and composite data sources. Molecular and cellular biomar....

2023-06-30

MedComm-Future Medicine | Recent advances of Transformers in medical image analysis: A comprehensive review

Flow chart of Transformer,1 which consists of positional encoding, Multi-Head Attention and feed-forward network. Copyright permission from Vaswani et al.Recent works have shown that Transformer's exc....

2023-05-31

MedComm-Future Medicine | Direct cellular targets and anticancer mechanisms of the natural product oridonin

Direct cellular targets of oridonin and the functions of oridonin-binding proteins. For each protein and associated pathway, the extent of inhibition depends on the concentration of oridonin applied. ....

2023-04-30

MedComm-Future Medicine | Antiangiogenic therapy for ocular diseases: Current status and challenges

Ocular neovascular diseases. (A) Normal eye structure. (B) Normal retinal structure of a representative area of a normal eye (the rectangular area in A). (C) In wet age-related macular degeneration (w....

2023-03-31

MedComm-Future Medicine | RNA modification pattern-based subtypes reveal heterogenous clinical outcomes and tumor immunity of clear cell renal cell carcinoma

Dysregulation and mutation profile of RNA modification regulators in pan-cancer. (A) The relative expression level of RNA modification regulators across cancer types. (B) The mutation frequencies of R....

2023-02-28