MedComm-Future Medicine | Metabolic insights into tumor pathogenesis: Unveiling pan-cancer metabolism and the potential of untargeted metabolomics

Metabolic profile of normal and tumor cells. Normal cells provide energy primarily through the tricarboxylic acid cycle, while tumor cells provide energy primarily through glycolysis even in the prese....

2023-09-30

MedComm-Biomaterials and Applications | Melatonin: Avenues in cancer therapy and its nanotechnological advancements

Prokaryotes to eukaryotes: MLT-preserved characteristics.Cancer is one of the most prevailing causes of mortality worldwide. Standard therapies for cancer patients include surgical intervention, chemo....

2023-09-30

MedComm-Oncology | Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistance

The structures of approved macrocyclic drugs and investigating macrocyclic compounds for cancer therapy.(A) Macrocyclic compounds to target cancer development. Compounds 1–2: macrocyclic peptide drugs....

2023-09-30

MedComm-Future Medicine | Chemoimmunotherapy for esophageal squamous cell carcinoma—Summary and discussion of recent clinical trials

Comparison between traditional chemotherapy and chemoimmunotherapy. Traditional standard chemotherapy contained alkylating agents, platinum, antimetabolites, microtubule inhibitors, and so on. Each of....

2023-08-31

MedComm-Biomaterials and Applications | Recent progress in thermosensitive hydrogels and their applications in drug delivery area

Classification of the thermosensitive hydrogel.The scientific community has widely recognized thermosensitive hydrogels as highly biocompatible material with immense potential in drug delivery systems....

2023-08-31

MedComm-Oncology | cGAS-STING signaling in cancer: Regulation and therapeutic targeting

The activation and translocation of STING. STING interacts with STIM1 and localizes on the ER. When STING is not yet activated, it is in a dimeric state with an open conformation. When STING is activa....

2023-08-31

MedComm-Future Medicine | Accelerating the integration of ChatGPT and other large-scale AI models into biomedical research and healthcare

Large-scale AI models. (A) Comparison of large-scale AIs with deep learning and machine learning. (B) Overview of the most recent advanced large-scale AI models and their sizes. A summary of the lates....

2023-07-31

MedComm-Future Medicine | Biomarkers of ageing: Current state-of-art, challenges, and opportunities

Ageing biomarkers are categorized based on the data sources utilized, encompassing molecular and cellular profiles, images, clinical measures, and composite data sources. Molecular and cellular biomar....

2023-06-30

MedComm-Future Medicine | Recent advances of Transformers in medical image analysis: A comprehensive review

Flow chart of Transformer,1 which consists of positional encoding, Multi-Head Attention and feed-forward network. Copyright permission from Vaswani et al.Recent works have shown that Transformer's exc....

2023-05-31