Molecular Biomedicine | CRISPR/Cas systems usher in a new era of disease treatment and diagnosis

Mechanisms of CRISPR/Cas system, BE and PEThe discovery and development of the CRISPR/Cas system is a milestone in precise medicine. CRISPR/Cas nucleases, base-editing (BE) and prime-editing (PE) are ....


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Molecular Biomedicine | The role of the gut microbiota in health and cardiovascular diseases

The gut microbiota helps maintaining the balance of the mucosal barrier and immune homeostasisThe gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithe....


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Molecular Biomedicine | Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy

The coat protein mediated vesicle formationIntracellular vesicle trafficking is the fundamental process to maintain the homeostasis of membrane-enclosed organelles in eukaryotic cells. These organelle....


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Molecular Biomedicine | The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding

C11ORF94 is a vertebrate derived transmembrane protein highly expressed in testisSperm-oocyte membrane fusion is necessary for mammalian fertilization. The factors that determine the fusion of sperm w....


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Molecular Biomedicine | Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment

Cellular properties of the photosensitizer ICG in vitroPhotodynamic therapy (PDT) has shown impressive therapeutic effects on various types of cancers by reactive oxygen species (ROS) generation and i....


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Molecular Biomedicine | MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis

Expression of miR-379-5p is decreased in vitro/in vivo/in clinic.Lipotoxicity induced by the overload of lipid in the liver, especially excess free cholesterol (FC), has been recognized as one of driv....


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Molecular Biomedicine | Significant perspectives on various viral infections targeted antiviral drugs and vaccines including COVID-19 pandemicity

Classification of infective human viral diseases and their characteristic sub division and familyA virus enters a living organism and recruits host metabolism to reproduce its own genome and proteins.....


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Molecular Biomedicine | A new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire

Schematic diagram of obtain CDR3 of neutralizing antibodies against SARS-CoV-2Although the SARS-CoV-2 vaccine has been widely used worldwide, not all individuals can produce neutralization antibodies,....


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COVID-19 metabolism: Mechanisms and therapeutic targets

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dysregulates antiviral signaling, immune response, and cell metabolism in human body. Viral genome and proteins hijack host metabolic netwo....