MedComm-Future Medicine | Cell-type-specific mRNA m6A landscape and regulatory mechanisms underlying pulmonary injury in COVID-19

Expression profile of N6-methyladenosine (m6A) regulators. (A) Uniform manifold approximation and projection (UMAP) plot of 116,252 nuclei from control individuals and Coronavirus disease 2019 (COVID-....

2024-08-31

MedComm-Biomaterials and Applications | Determining the effects of varying blood storage conditions on clot formation and digestion under shear

Schematic outline of whole blood fractionation and storage protocol with Chandler loop clot formation under shear, thromboelastography, tPA (tissue plasminogen activator) clot lysis, and histology met....

2024-08-31

MedComm-Oncology | Enhancing cancer immunotherapy and antiangiogenic therapy by regulating gut microbes: Opportunities and challenges

Immune suppressive microenvironment induced by abnormal tumor vasculature. Hypoxia and acidosis in the tumor microenvironment (TME) are caused by vascular abnormalities in the tumor, which in turn can....

2024-08-31

MedComm-Future Medicine | Cordyceps sinensis ameliorates idiopathic pulmonary fibrosis in mice via inhibiting mitochondrion-mediated oxidative stress

Cordyceps sinensis ameliorated bleomycin-induced idiopathic pulmonary fibrosis in mice. (A) Schematic representation of the model establishment and drug treatment regimen for pulmonary fibrosis in mic....

2024-07-31

MedComm-Biomaterials and Applications | Tissue-engineered vascular grafts for cardiovascular disease management: Current strategies, challenges, and future perspectives

Design for nanofiberous graft based on PGA/PLCL: (A, B) Measuring dimensions and shape of thoracic inferior vena cava in sheep model using angiography. (C) Computer-aided design 3D-printed mandrel for....

2024-07-31

MedComm-Oncology | Next-generation sequencing identifies that protein tyrosine phosphatase receptor type D mutation is favorable to immunotherapy in human cancer

Protein tyrosine phosphatase receptor type D-mutation (PTPRD-MUT) was favorable to immunotherapy in the discovery cohort. (A) The genomic mutation signatures of PTPRs. (B) The co-occurrence and mutual....

2024-07-31

MedComm-Future Medicine | Unraveling the influence of metabolic signatures on immune dynamics for predicting immunotherapy response and survival in cancer

Overall Survival analysis in metabolism-based classes. (A) Nonnegative matrix factorization clustering algorithm by metabolism genes in training cohort. (B) Kaplan–Meier curve of patients in the train....

2024-06-30

MedComm-Biomaterials and Applications | Evaluation of cell-laden three-dimensional bioprinted polymer composite scaffolds based on synthesized photocrosslinkable poly(ethylene glycol) dimethacrylate with different molecular weights

Schematic representation of bioprinting using poly(ethylene glycol) dimethacrylate (PEGDMA). LAP, lithium phenyl-2,4,6-trimethyl benzoyl phosphinate.This manuscript aims to three-dimensional bioprint ....

2024-06-30

MedComm-Oncology | Clinical homologous recombination repair gene reversion analysis identifies mechanisms of resistance to PARP inhibitors and platinum-chemotherapy

Study design. The 25 pre-defined HRR genes covered by the NGS panel is shown. Patient screening flow is demonstrated with the rationale of the four-tier classification. HRR, homologous recombination r....

2024-06-30