MedComm-Future Medicine | Direct cellular targets and anticancer mechanisms of the natural product oridonin

Direct cellular targets of oridonin and the functions of oridonin-binding proteins. For each protein and associated pathway, the extent of inhibition depends on the concentration of oridonin applied. ....

2023-04-30

MedComm-Future Medicine | Antiangiogenic therapy for ocular diseases: Current status and challenges

Ocular neovascular diseases. (A) Normal eye structure. (B) Normal retinal structure of a representative area of a normal eye (the rectangular area in A). (C) In wet age-related macular degeneration (w....

2023-03-31

MedComm-Future Medicine | RNA modification pattern-based subtypes reveal heterogenous clinical outcomes and tumor immunity of clear cell renal cell carcinoma

Dysregulation and mutation profile of RNA modification regulators in pan-cancer. (A) The relative expression level of RNA modification regulators across cancer types. (B) The mutation frequencies of R....

2023-02-28

MedComm-Future Medicine | VDDB: A comprehensive resource and machine learning tool for antiviral drug discovery

Potential antivirals in VDDB. (A) Annotated entry for each vaccine. (B) Annotated entry for each antibody. (C) Annotated entry for each small molecule. (D) Classification of viruses.Virus infection is....

2023-01-31

MedComm-Biomaterials and Applications | DNA origami technology for biomedical applications: Challenges and opportunities

DNA origami technology. (A) Schematic shows the fabrication process of classic DNA origami nanostructures. (B) Representative two-dimensional DNA origami shapes. (C) Representative three-dimensional m....

2023-07-31

MedComm-Biomaterials and Applications | Nanotechnology connecting copper metabolism and tumor therapy

The strategy and applications of copper metabolism-based cancer therapy.Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such a....

2023-06-30

MedComm-Biomaterials and Applications | Recent progress in orodispersible films-mediated therapeutic applications: A review

(A) Orodispersible films (ODFs) embedded with poorly water-soluble active pharmaceutical ingredients (APIs) formulated by various formulation strategies (image reprinted with permission from Ref.Orodi....

2023-05-31

MedComm-Biomaterials and Applications | Nanobiotechnology-mediated radioimmunotherapy treatment for triple-negative breast cancer

Mechanism of radiotherapy-induced abscopal effect combined with immunotherapy. CTLA-4, cytotoxic T-lymphocyte-associated antigen 4; PD-1, programmed death 1; PD-L1, programmed death-ligand 1; TNBC, tr....

2023-04-30

MedComm-Biomaterials and Applications | Dendrimer and dendrimer gel-derived drug delivery systems: Breaking bottlenecks of topical administration of glaucoma medications

Two major barriers to topical ocular drug delivery. Reprinted with permission from Li et al.Due to high structural flexibility, multidrug carrying capability, and tunable size, dendrimers have been us....

2023-03-31