MedComm-oncology | Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy

The two major angiogenic signaling pathways involved in vessel formation. Schematic representation of sequential events that take place under activation of angiogenesis. The paradigm follows the activ....

2023-03-31

MedComm-oncology | Morus alba derived Kuwanon-A combined with 5-fluorouracil reduce tumor progression via synergistic activation of GADD153 in gastric cancer

Schematic illustrating the potential pathway associated with the apoptosis-inducing effect of Kuwanon-A (KA) and 5-fluorouracil (5-FU) on gastric cancer (GC) cells.Despite the application of conventio....

2023-02-28

MedComm-oncology | Oncolytic virotherapy using neural stem cells as a novel treatment option for glioblastoma multiforme

Oncolytic virus (OV) activation of both systemic and local antitumor immunity. After OV infection, cell death, and the release of tumor-associated antigens, tumor-specific immune responses increase an....

2023-01-31

MedComm | M2-like macrophage-derived exosomes facilitate metastasis in non-small-cell lung cancer by delivering integrin αVβ3

A high integrin αVβ3 level is associated with non-small-cell lung cancer metastasis and a poor prognosisMetastasis is the most prevalent cause of cancer deaths, and immunological components of the tum....

2022-12-23

MedComm

 
MedComm | Targeting inorganic nanoparticles to tumors using biological membrane-coated technology

Schematic illustration of novel approaches for biomimetic precision antitumor strategies based on biological membrane-coated inorganic nanoparticlesInorganic nanoparticles have extensively revolutioni....

2022-12-08

MedComm

 
MedComm | ENKUR recruits FBXW7 to ubiquitinate and degrade MYH9 and further suppress MYH9-induced deubiquitination of β-catenin to block gastric cancer metastasis

ENKUR inhibits MYH9 expression by recruiting the E3 ubiquitin ligase FBXW7 to promote its protein ubiquitinated degradation. Downregulated MYH9 further increased the degradation of β-catenin protein b....

2022-11-25

MedComm

 
MedComm | Role of protein phosphorylation in cell signaling, disease, and the intervention therapy

Schematic diagram of protein phosphorylation signaling pathway of protein kinase A, G, and C (AGC)-receptor guanylate cyclase (RGC) groupProtein phosphorylation is an important post-transcriptional mo....

2022-11-03

MedComm

 
MedComm | Integrated analyses of brain and platelet omics reveal their common altered and driven molecules in Alzheimer's disease

The altered brain and platelet key proteins and their network linkage in AD patients.Platelets may serve as a perfect peripheral source for exploring diagnostic biomarkers for Alzheimer's disease (AD)....

2022-10-13

MedComm

 
MedComm | Small molecule inhibitors targeting the cancers

Mechanisms of secondary resistance of small molecule inhibitors and countermeasuresCompared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and tolerability. Small mo....

2022-10-13

MedComm