STTT | NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including n....



Molecular Biomedicine | cGAS/STING: novel perspectives of the classic pathway

Researchers summerized the role cGAS/STING pathway plays in various pathological and physiological process and emphasized its involvment in some “nontraditional” way.


Mol Biomed

Molecular Biomedicine | Development of a novel TLR8 agonist for cancer immunotherapy

Toll-like receptors (TLRs) play a vital role in both innate and adaptive immune responses, which means they are also indispensable in tumorigenesis. Up to now, some TLRs, such as TLR8, TLR4, TLR7 and ....


Mol Biomed

Molecular Biomedicine | Revisiting cancer hallmarks: insights from the interplay between oxidative stress and non-coding RNAs

Cancer is one of the most common disease worldwide, with complex changes and certain traits which have been described as “The Hallmarks of Cancer.” Despite increasing studies on in-depth investigation....


Mol Biomed

MedComm | Is there a maximal effect of tranexamic acid in patients undergoing total knee arthroplasty? A randomized controlled trial

Surgical trauma after Total knee arthroplasty (TKA) is always companied by significant hyperfibrinolysis, which can lead to considerable blood loss and rising demand for blood transfusions. Therefore,....



MedComm | Interference of miR‐107 with Atg12 is inhibited by HULC to promote metastasis of hepatocellular carcinoma

Highly upregulated in liver cancer (HULC) was proposed as a diagnosis biomarker in hepatocellular carcinoma (HCC). Both HULC and autophagy are closely correlated with Epithelial-mesenchymal transition....



Molecular Biomedicine | Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2

Recently, COVID-19 has raised significant public health concerns globally. However, the some pivotal structure of the causative agent, SARS-CoV-2, is yet not quite clear. In this study, Dan Su et al. ....


Mol Biomed

Molecular Biomedicine - Progress in exosome associated tumor markers and their detection methods

In recent years, the tumor-derived exosome has been perceived as a hot and emerging biomarker for various cancers diagnosis and management in non-invasive manner. However, the problem of exosome isola....


Mol Biomed

MedComm | Radiomics‐based model for accurately distinguishing between severe acute respiratory syndrome associated coronavirus 2 (SARS‐CoV‐2) and influenza A infected pneumonia

The spread of coronavirus disease 2019 (COVID‐19) has become a global pandemic and public health problem. Although unprecedented efforts had been concentrated to identify and isolate individuals with ....