MedComm | Small extracellular vesicles‐based cell‐free strategies for therapy

Small extracellular vesicles (sEVs) are extracellular nanovesicles that contain bioactive proteins, lipids, RNA, and DNA. A variety of biological process is regulated with sEVs. sEVs are an intercellu....



Molecular Biomedicine | Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia

Pluripotent stem cells in embryo can self-renew and can generate all mature cell types in the body as their potency to self-renew progressively decreases. Adult organs possess populations of tissue-re....


Mol Biomed

MedComm | Autophagic activation of IRF‐1 aggravates hepatic ischemia–reperfusion injury via JNK signaling

Increasing evidence has accrued indicating that autophagy is associated with hepatic ischemia–reperfusion injury (IRI). This report demonstrates that interferon regulatory factor‐1 (IRF‐1) was upregul....



MedComm | A potent neutralizing nanobody against SARS-CoV-2 with inhaled delivery potential

The world-wide spread of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is the third major coronavirus outbreak in the past 20 years. SARS-CoV-2 is closely related to SARS-CoV, several SARS-....



Molecular Biomedicine| Cancer metabolism and intervention therapy

Metabolic reprogramming with heterogeneity is a hallmark of cancer and is at the basis of malignant behaviors. It supports the proliferation and metastasis of tumor cells according to the low nutritio....


Mol Biomed

MedComm | Construction of a risk map to understand the vulnerability of various types of cancer patients to COVID-19 infection

COVID-19 is leading to a global pandemic and invades human cells via ACE2. So ACE2 is considered to be the receptor in host cells for binding to this novel virus. Therefore, the target cells with the ....



MedComm | Advances in pathogenesis and precision medicine for nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a squamous carcinoma involving genetic predisposition, infection with Epstein-Barr virus (EBV), and environmental factors, with apparent geographical and racial distr....



Molecular Biomedicine | GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation

Ran (Ras-related nuclear) protein is a member of the Ras superfamily of small GTPases. Like other GTPases, Ran switches between GDP-bound (inactive) and GTP-bound (active) states. Multiple missense mu....


Mol Biomed

MedComm | Lipid metabolism in cancer progression and therapeutic strategies

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy producers, signa....