Molecular Biomedicine | GMPPB-congenital disorders of glycosylation associate with decreased enzymatic activity of GMPPB

The congenital disorders of glycosylation (CDG) are a family of metabolic diseases in which glycosylation of proteins or lipids is deficient. GDP-mannose pyrophosphorylase B (GMPPB) mutations lead to ....

2021-05-10

Mol Biomed

 
MedComm | Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increa....

2021-02-25

MedComm

 
Molecular Biomedicine | Interplay between SMAD2 and STAT5A is a critical determinant of IL-17A/IL-17F differential expression

Interleukins (IL)-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-hel....

2021-04-01

Mol Biomed

 
MedComm | Small extracellular vesicles‐based cell‐free strategies for therapy

Small extracellular vesicles (sEVs) are extracellular nanovesicles that contain bioactive proteins, lipids, RNA, and DNA. A variety of biological process is regulated with sEVs. sEVs are an intercellu....

2021-02-18

MedComm

 
Molecular Biomedicine | Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia

Pluripotent stem cells in embryo can self-renew and can generate all mature cell types in the body as their potency to self-renew progressively decreases. Adult organs possess populations of tissue-re....

2021-03-10

Mol Biomed

 
MedComm | Autophagic activation of IRF‐1 aggravates hepatic ischemia–reperfusion injury via JNK signaling

Increasing evidence has accrued indicating that autophagy is associated with hepatic ischemia–reperfusion injury (IRI). This report demonstrates that interferon regulatory factor‐1 (IRF‐1) was upregul....

2021-02-11

MedComm

 
MedComm | A potent neutralizing nanobody against SARS-CoV-2 with inhaled delivery potential

The world-wide spread of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is the third major coronavirus outbreak in the past 20 years. SARS-CoV-2 is closely related to SARS-CoV, several SARS-....

2021-03-19

MedComm

 
Molecular Biomedicine| Cancer metabolism and intervention therapy

Metabolic reprogramming with heterogeneity is a hallmark of cancer and is at the basis of malignant behaviors. It supports the proliferation and metastasis of tumor cells according to the low nutritio....

2021-02-27

Mol Biomed

 
MedComm | Construction of a risk map to understand the vulnerability of various types of cancer patients to COVID-19 infection

COVID-19 is leading to a global pandemic and invades human cells via ACE2. So ACE2 is considered to be the receptor in host cells for binding to this novel virus. Therefore, the target cells with the ....

2021-02-22

MedComm