MedComm | A dual MET/AXL small‐molecule inhibitor exerts efficacy against gastric carcinoma through killing cancer cells as well as modulating tumor microenvironment


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There are two kinds of receptor tyrosine kinases --MET and AXL --which are intimately bound up with tumorigenesis and aggressiveness of multiple malignancies. However, the molecular mechanism of MET and AXL in both processes is yet not quite clear. In the present study, Chenjing Zhu et al evaluated the antitumor impact of LY2801653, a dual MET and AXL inhibitor on gastric cancer and to elucidate the underlying mechanisms.

Fig. 1 MET and AXL expression in human gastric cancer cell lines and gastric cancer patients’ tumors.




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