MedComm | Intermedin promotes vessel fusion by inducing VE‐cadherin accumulation at potential fusion sites and to achieve a dynamic balance between VE‐cadherin‐complex dissociation/reconstitution


Open the phone and scan

A closed vascular system is always established by vessel fusion. However, it has been an unsolved mystery that how vessel fusion happened in this process. In this study, Lingmiao Kong et al reported that intermedin (IMD), a calcitonin family member, promotes vessel fusion by inducing endothelial cells (ECs) to enter a “ready‐to‐anchor” state.

Fig. 1 IMD promotes vessel fusion in vitro and in vivo.




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