In the afternoon of December 16, 2022, the “2022 STTT International Biomedical Conference— The International Innovation Forum for Young Talents”, sponsored by Sichuan International Medical Exchange & Promotion Association (SCIMEA), Signal Transduction and Targeted Therapy of West China Hospital of Sichuan University and the State Key Laboratory of Biotherapy at West China Hospital of Sichuan University, was successfully held at Jinjiang Hotel, Chengdu in an online and offline manner. In this special period of severe epidemic, students and faculty attending the forum brought a unique international academic exchange feast, showing the positive expectations of young people for the future.

Scene of the conference

The forum focused on the theme of “Basic and Translational Research on Molecular Signal Transduction and Diseases”, inviting postgraduate students from domestic and foreign universities in clinical medicine to exchange and share the frontier progress and explore ideas related to the pathophysiological mechanism of “Molecular Signal Transduction and Diseases”. 

The opening ceremony invited Academician Wei Yuquan, Editor-in-chief of the journal Signal Transduction and Targeted Therapy of West China Hospital, Sichuan University, and Su Baihai, Director of the Postgraduate Department of West China Hospital, Sichuan University, to deliver speeches.

Academician Wei Yuquan, Editor-in-chief of the journal Signal Transduction and Targeted Therapy of West China Hospital, Sichuan University, delivers a speech.

On behalf of STTT, Academician Wei expressed his warm congratulations on the successful convening of the conference. He pointed out that under the serious situation of the COVID-19 epidemic, the young scholars still insisted on academic exchanges as scheduled, which demonstrated the pursuit spirit of young scholars who are not afraid of challenges ad dare to climb to the peak. He was deeply moved by and admired the dedication and pursuit of academic excellence of the young scholars.  He also hoped that through academic exchanges, young scholars can irrigate the source of knowledge, deepen the foundation of knowledge, ignite the engine of hard work with passion, and release the power of youth!

Prof. Su Baihai, Director of the Postgraduate Department of West China Hospital, Sichuan University, delivers a speech.

Prof. Su said that the development of medicine always requires young people to climb to the top and keep striving to move forward. The West China School of Medicine is committed to building a "competency-based" system of medical talent excellence. In addition to the basic clinical skills, it is more important to develop a sense of innovation and scientific thinking in the postgraduate training.  We need not only high-quality basic research, but also innovative research results. He expected the young scholars to make further progress and achieve better results through innovation.

Wei Xiawei, a research fellow of West China Hospital, Sichuan University, presides over the opening ceremony.

The opening ceremony of the conference was presided over by researcher Wei Xiawei, a research fellow and Director of International Cooperation and Exchange Office/Hong Kong, Macao and Taiwan Affairs Office, West China Hospital, Sichuan University. Ms. Wei introduced that this conference aims to promote the international vision and academic growth of graduate students and enhance the influence of STTT among young scholars. A total of 30 excellent abstracts were selected for presentation at this forum, covering international cutting-edge clinical basic and translational research.

Academic Presentation

Oral Presentation I

Wei Xiawei, a research fellow of West China Hospital, Sichuan University, chairs the session.

Tian Xiaohe, a research fellow of West China Hospital, Sichuan University, chairs the session.

The first part of the academic presentation was chaired by Wei Xiawei and Tian Xiaohe, research fellows of West China Hospital, Sichuan University. The oral presentations were conducted in English, fully demonstrating the latest research progress and international perspective of the presenters.

“Histones Released by NETosis Enhanced the Infectivity of SARS-CoV-2 by Bridging the Spike Protein Subunit 2 and Sialic Acid on Host Cells”, by Hong Weiqi, the State Key Laboratory of Biotherapy at West China Hospital, Sichuan University

“Up-regulated Clusterin and Epithelial to Mesenchymal Transition Induced by TGFβ1-smad2/3-Twsit1 Pathway Contributes to Kidney Stone Formation”, by Ma Yucheng, West China Hospital, Sichuan University

“Glucose-Responsive Microneedle Patch for Closed-Loop Dual-Hormone Delivery in Mice and Pigs”, by Yang Changwei, Zhejiang University

“Lipid Nanoparticle-mediated Delivery of mRNA Vaccine Elicits HPV-specific CD8+T Cell Expansion and Promotes Tumor Regression”, by Qiu Ke, West China Hospital, Sichuan University

“Fostering Mycobacterium Tuberculosis Clearance through Remodulation of the Histone Epigenetic Landscape”, by Stefano Muzzioli, Milan University, Italy

“Allosteric Modulation of G protein-coupled Receptor Signal Transduction”, by Zhao Chang, the State Key Laboratory of Biotherapy at West China Hospital, Sichuan University

“Tranylcypromine-Conjugated NMethylpropargylamine as Lysine Specific Demethylase 1(LSD1) Inhibitors for Cancer Treatment”, by Zhang Jingya, Zhengzhou University

“Integrating Single-cell RNA Sequencing with Spatial Transcriptomics Reveals Immune Landscape for Interstitial Cystitis”, by Peng Liao, West China Hospital, Sichuan University

“Circular RNA circPTK2 as a Novel Oncogenic Driver to Promote Tumor Metastasis via the Nucleolin/P53/E-cadherin Axis in Hepatocellular Carcinoma”, by Hu Xin, Zhejiang University

“Targeting CRL4 Suppresses Chemoresistant Ovarian Cancer Growth by Inducing Mitophagy”, by Meng Yang, the State Key Laboratory of Biotherapy at West China Hospital, Sichuan University

“Development of Radiogenomic Model to Predict Egfr Mutation Status, Subtypes, and Survival Based on CR Images in Lung Cancer”, by Shao Jun, West China Hospital, Sichuan University 

“Exercise-induced Myokine Preventing Fatty Infiltration through Regulating the Adipogenesis of Fibro/Adipogenic Progenitors in Injured Muscles”, by Kang Xia, the Third Military Medical University

“ANXA1 Promotes Acute Myeloid Leukemia Cell Proliferation by s Mechanism of Antagonizing the Notch1-P15-mediated Tumor Suppression”, by Shao Gang, Zhejiang Sci-Tech University

“Upregulation of PIK3IP1 Monitors the Anti-Cancer Activity of PI3Kα Inhibitors in Gastric Cancer Cells”, by Ma Xubin, Zhengzhou University

Oral Presentation II

Assoc. Prof. Luo Deyi from West China Hospital of Sichuan University chairs the session.

Huang Wei, a research fellow of West China Hospital, Sichuan University, chairs the session.

The second part of the academic presentation session of this forum was chaired by Assoc. Prof. Luo Deyi and Huang Wei, a research fellow of West China Hospital of Sichuan University. They actively organized young scholars to exchange innovative ideas and guided them to show their innovative style of daring to think and act.

“Identifying a Confused Cell Identity for Esophageal Squamous Cell Carcinoma”, by Pan Xiangyu, West China Hospital, Sichuan University

“Innate Immune Regulation of Endothelial Cells Is Involved in Myocardial Ischemic Fibrosis Injury through Deep Learning”, by Zuo Xinrong, Affiliated Hospital of Southwest Medical University

“MicroRNA-26a Inhibits Development of Acute Pancreatitis by Attenuating Calcium Overload”, by Liu Shiyu, West China Hospital, Sichuan University

“miR-125b-5p Modulates the Function of Regulatory T Cells and Facilitates Anti-Tumor Immune Responses by Targeting TNFR2”, by Jiang Mengmeng, University of Macau

“PMPC-PDPA Polymersomes in Cancer Vaccine Development”, by Bárbara Ibarzo Yus, University College London

“Single-cell Transcriptomic Profiling Unravels the Adenoma-Initiation Role of Protein Tyrosine Kinases during Colorectal Tumorigenesis”, by Yin Xiaomeng, West China Hospital, Sichuan University

“BUB1B and circBUB1B_544aa Aggravate Multiple Myeloma Malignancy through Evoking Chromosomal Instability”, by Wang Chen, Nanjing University of Chinese Medicine

“Enhanced Production of Metallothionein Is Responsible for Zinc-Glutathione Suppression of Chronic Alcoholic Liver Injury in Mice”, by Feng Yinrui, West China Hospital, Sichuan University

“A Novel GABAA Receptor Agonist that Regulates Nerve Conduction and Consciousness”, by Liu Tianyou, West China Hospital, Sichuan University

“Establishment of an Oral Intelligent Medical Management Platform”, by Tian Erkang, Sichuan University

“Multi-omic Analysis on the Role and Molecular Mechanisms of Metabolic Dysregulation in Sarcopenia”, by Xiang Qiao, West China Hospital, Sichuan University

“Selenium Binding Protein 1 (SELENBP1) Inhibits Malignant Progression and Induces Apoptosis via Distinct Mechanisms in Non-Small-Cell Lung Cancer”, by Zhu Ying, West China Hospital, Sichuan University

“Discovery of the First Picomolar PPAR/Dual Agonist for the Treatment of Cholestatic Liver Diseases”, by Sun Gang, China Pharmaceutical University

“Transcatheter Aortic Valve Replacement in Type 0 Bicuspid, Type 1 Bicuspid and Tricuspid Aortic Stenosis”, by He Jingjing, West China Hospital, Sichuan University

“Size-tunable Gold Nanoparticles for Tumor Radiosensitization and Synergistic Chemoradiotherapy”, by Luan Siyuan, Sichuan University

Award Ceremony

Sun Qiu, an associate research fellow of STTT, West China Hospital, Sichuan University, chairs the award ceremony.

The “Excellent Report Award Ceremony” was held grandly. The ceremony was chaired by Sun Qiu, an associate research fellow of STTT, West China Hospital, Sichuan University. Wang Wenjing, Associate Editor of STTT, West China Hospital, Sichuan University, and Prof. Deng Cheng of West China Hospital, Sichuan University served as the award presenters to award prizes to excellent reports.

Group photo of award ceremony

The forum followed the theme of "Promoting International Exchange and Youth Growth" and adopted various forms of academic discussions, such as oral presentations, on-site Q&A and interactive exchanges. The forum showcased the latest academic research achievements in molecular signal transduction, discussed the frontier issues in life science, and explored the international vision of young scholars. It also established an international academic exchange platform to inject more youth power to promote the construction of a healthy China!

Group photo of the conference